Based on limited data, occupational exposure of women to metallic antimony and several antimonials has reportedly … It is brought into this country from other countries for processing. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. Symptomatic and supportive treatment is most commonly used in antimony toxicity. In general, how your body reacts to a toxic level of antimony will depend on how you were exposed. 1.9 What recommendations has the federal government made to protect human health? Chelation Therapy; Chelation therapy with BAL, DMSA, or DMPS has been shown to improve the course of antimony toxicity. Email: Contact CDC-INFO. Common symptoms of poisoning from these metals may include gastrointestinal, renal, and neurological symptoms, such as headaches, irritability, psychosis, stupor, coma, and convulsions. When your body accumulates antimony over time it influences and raises your blood cholesterol while at the same time can decrease your blood sugar level. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardio toxicity. It is also used in paints, ceramics, and fireworks, and as enamels for plastics, metal, and glass. Little antimony is currently mined in the United States. The level in urine is normally around 250 ppt (which is equivalent to a mere 0.000000025%). Toxicological Other Therapies Gross exposure to antimony compounds o … Stibine is a metal hydride form of antimony us… Antimony occurs naturally in the earth. Treatment. Antimony: A silvery-white earth metal which at high levels can be toxic. Antimony levels as high as 9.7 µg/L have been reported in drinking water. Blood levels of antimony can be measured to confirm diagnosis of antimony toxicity. The most widely used antimony compound is antimony trioxide, used as a component in flame retardant applications. Heavy metals are deadly hidden toxins in our food and environment. It is used in metal alloys, storage batteries, solder, sheet and pipe metal, ammunition, metal bearings, castings, and pewter. [] conducted several laboratory experiments to investigate whether elevated antimony concentrations previously found in the organs of wild, short-tailed field voles (Microtus agrestis) at a contaminated grassland site near an antimony smelter were sufficient to cause harmful … For this reason, some items on this page will be unavailable. You … Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. Ingestion. The effects are hypothesized to be attributed to inhalation of poorly solubl… Profile for antimony, Toxicological In general, how your body reacts to a toxic level of antimony will depend on how you were exposed. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. In accordance with the diantimony trioxide CSR, the NOAEL of 1686 mg/kg bw/d from a subchronic oral toxicity study in rats is selected as being the most relevant for estimating systemic effects that might be associated with dermal uptake of antimony metal or antimony (III) compounds. In certain cases when the Antimony levels are higher than expected, the associated … Antimony is a silvery-white metal that is found in the earth's crust. It roughly makes up about 0.00002 percent of the Earth’s crust. cadmium, mercury). Antimony oxide (Sb2O4) Diantimony tetraoxide. As covered in a recent article, Toxic Chemicals in Children’s Toys, it is one of eight heavy metals limited by the CPSC in the manufacture of products for children 12 years old or younger. Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. For this reason, some items on this page will be unavailable. Antimony is a rare element part of the metalloid group in the periodic table. Acute (short-term) exposure to antimony by inhalation in humans results in effects on the skin and eyes. 1.8 Is there a medical test to determine whether I have been exposed to Antimony? Antimony poisoning has resulted from drinking acidic fruit juices containing antimony oxide dissolved from the glaze of cheap enamelware containers. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. This guide will inform you of sources of toxic heavy metals, symptoms of toxicity and how to remove them from your body. Antimony oxide is added to textiles and plastics to prevent them from catching fire. The form of antimony greatly influences distribution and elimination. EINECS 215-576-0. Symptoms of antimony poisoning, when exposed to small doses, include headache, nausea, and depression. The metal is usually alloyed with other alloys to increase its viability in the manufacturing industry where it is used to help make certain semiconductor devices. Toxicological Information . It is brought into this country from other countries for processing. Antimony trichloride (SbCl 3 ), or antimonous chloride (butter of antimony) , is produced by the interaction of chlorine and antimony or by dissolving antimony trisulphide in hydrochloric acid. It is also used as a catalyst to produce polyester, and is found in plastics used for disposable beverage bottles. Antimony Trioxide (CASRN 1309-64-4) Superfund Health Risk Technical Support Center . (1999) evaluated serum cytokine and immunoglobulin levels in antimony workers at a factory in Korea that produced antimony trioxide as a major product. It is brought into this country from other countries for processing. Provisional Peer Reviewed Toxicity Values for . Inhalation of antimony trioxide (and similar poorly soluble Sb(III) dust particles such as antimony dust) is considered harmful and suspected of causing cancer. Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. 7440-36-0. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. The toxicokinetics and toxicity of the tri- and pentavalent forms vary, with the trivalent form considered to be more toxic. The tri- and pentavalent forms are the most stable forms of antimony (U.S. EPA, 1992) and are of the most interest in biological systems. Routes Of Exposure: Eye contact. Antimony is a naturally occurring metal often used in combination with lead and zinc, found in metal alloys, paints, ceramics, and fireworks. Ainsworth et al. The toxicology of antimony and its compounds is known from three sources: its medicinal use over centuries, studies of process workers in more recent times, and more recent still, studies of its presence in modern city environments and in domestic environments. Water in PET bottles may contain higher levels of antimony. Basis for revised IDLH: The revised IDLH for antimony compounds is 50 mg Sb/m3 based on acute inhalation toxicity data in animals [Izmerov et al. CDC has established ranges for urine levels of antimony in the U.S. population: 0.120–0.364 micrograms/gram creatinine. ANTIMONY. At relatively low levels, lead can participate in synergistic toxicity with other toxic elements (e.g. Everyone is exposed to low levels of antimony in the environment. Antimony can exist in one of four valences in its various chemical and physical forms: -3, 0, +3, and +5. Note: Javascript is disabled or is not supported by your browser. Summary: Antimony is a silvery-white metal that is found in the earth's crust. Antimony is a silvery-white metal that is found in the earth's crust. Summary of mammalian toxicity Mammalian Oral Toxicity Mammalian Oral Toxicity—Acute. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. However, no TESTING: If you suspect that you have an elevated Lead level, it is important for you to know that whole blood analysis can reflect only recent exposures and does not correlate well with total body burden of lead. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. Little antimony is currently mined in the United States. Note: Javascript is disabled or is not supported by your browser. However, these effects are only observed with female rats and after long-term exposure to high dust concentrations. The CDC stated in their report that only validated methods should be used for the determination of antimony toxicity. Antimony is used for hardening lead, and in the manufacture of batteries and cables. The effects of antimony and its compounds on human and environmental health differ widely. It is also used in paints, ceramics, fireworks, enamels, and glass, and as a fire-retardant in textiles and plastics. ATSDR can also tell you the location of occupational and environmental health clinics. However, even these doses can be fatal when chronically exposed. Blood antimony levels predominantly reflect recent exposure and are most useful in the diagnosis of acute poisoning. The study The background level of antimony in bodily fluids used to be almost undetectable but techniques have improved in recent years so that it is now measurable at parts per trillion. 1982] and an analogy to hydrogen chloride [ACGIH 1991] which has a revised IDLH of 50 ppm (75 mg/m3). Antimony is found in ores or other minerals, often combined with oxygen to form antimony trioxide or with sulfur to form stibnite. Antimony exists in valences of 0, -3, +3, +5. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Antimony is a metalloid with an atomic number of 51. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Usually, the toxic effects of metals are related to the chemical form to which peoples are exposed. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. 1.7 How can families reduce the risk of exposure to Antimony? Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. 1.4 How can Antimony enter and leave my body? These clinics specialize in Skin contact. Antimony levels for these occupational exposure evaluations ranged from 2.2 to 11.98 mg Sb/m 3. Antimony pentasulphide (Sb 2 S 5) has much the same uses as the trisulphide and has a low level of toxicity. DTXSID9061677 ... Kim et al. 888-232-6348 (TTY) However, there are companies in the United States that produce antimony as a by-product of smelting lead and other metals. Hazard Summary. Decomposition Products: Antimony, antimony oxides, s ulfur oxides and hydrogen sulfide. profile for antimony, Agency for Toxic Substances and Disease Registry. Elemental antimony metal does not affect human and environmental health. ANTIMONY TETROXIDE. Long-term occupational exposure of humans has resulted in electrocardiac disorders, respiratory disorders, and possibly increased mortality (Renes, 1953; Breiger et al., 1954). Inhalation. Health Dangers of Antimony. protozoic treatment. Methods: We included observational studies that measured levels of toxic metals (antimony, arsenic, cadmium, lead, manganese, mercury, nickel, silver, and thallium) in different specimens (whole blood, plasma, serum, red cells, hair and urine) for patients with ASD and for controls. RTECS Number: CC9450000 . Provides an ongoing assessment of the exposure of the U.S. population to environmental chemicals using biomonitoring. Chronic Toxic Effects: This product ha s not been fully tested. Those who breathed in the compound, like the port workers mentioned above, may suffer from symptoms like pneumoconiosis, gastrointestinal concerns, antimony spots appearing on their skin, and respiratory irritation. Antimony isn't used alone because it breaks easily, but when mixed into alloys, it is used in lead storage batteries, solder, sheet and pipe metal, bearings, castings, and pewter. Little antimony is currently mined in the United States. 1.2 What happens to Antimony when it enters the environment? According to an article done by De Wolffe, a professor of toxicology at thew University of Amsterdam, antimony toxicity does not exist; and every compound of the metal must be considered to be a separate toxicological entity. 11. Toxicity Data: LD50 Oral – Rat >2,000 mg/kg . 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